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| 19. |  | BENAVIDES, M. V.; SONSTEGARD, T. S.; KEMP, S.; MUGAMBI, J. M.; GIBSON, J. P.; BAKER, R. L.; HANOTTE, O.; MARSHALL, K.; VAN TASSELL, C. Identification of novel loci associated with gastrointestinal parasite resistance in a Red Maasai x Dorper backcross population. Plos One, v. 10, n. 4, e0122797, Apr. 2015.| Biblioteca(s): Embrapa Pecuária Sul; Embrapa Pesca e Aquicultura. |
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| 20. | | TIJJANI, A.; SALIM, B.; SILVA, M. V. G. B.; ELTAHIR, H. A.; MUSA, T. H.; MARSHALL, K.; HANOTTE, O.; MUSA, H. H. Genomic signatures for drylands adaptation at gene-rich regions in African zebu cattle. Genomics, v. 114, 110423, 2022.| Biblioteca(s): Embrapa Gado de Leite. |
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Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
21/07/2022 |
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Data da última atualização: |
21/07/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
TIJJANI, A.; SALIM, B.; SILVA, M. V. G. B.; ELTAHIR, H. A.; MUSA, T. H.; MARSHALL, K.; HANOTTE, O.; MUSA, H. H. |
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Afiliação: |
ABDULFATAI TIJJANI, International Livestock Research Institute - ILRI; BASHIR SALIM, University of Khartoum; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; HAMZA A. ELTAHIR, University of Nyala; TAHA H. MUSA, Darfur College; KAREN MARSHALL, International Livestock Research Institute - ILRI; OLIVIER HANOTTE, International Livestock Research Institute - ILRI; HASSAN H. MUSA, University of Nyala. |
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Título: |
Genomic signatures for drylands adaptation at gene-rich regions in African zebu cattle. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Genomics, v. 114, 110423, 2022. |
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DOI: |
https://doi.org/10.1016/j.ygeno.2022.110423 |
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Idioma: |
Inglês |
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Conteúdo: |
Background - Indigenous Sudanese cattle are mainly indicine/zebu (humped) type. They thrive in the harshest dryland environments characterised by high temperatures, long seasonal dry periods, nutritional shortages, and vector disease challenges. Here, we sequenced 60 indigenous Sudanese cattle from six indigenous breeds and analysed the data using three genomic scan approaches to unravel cattle adaptation to the African dryland region. Results - We identified a set of gene-rich selective sweep regions, detected mostly on chromosomes 5, 7 and 19, shared across African and Gir zebu. These include genes involved in immune response, body size and conformation, and heat stress response. We also identified selective sweep regions unique to Sudanese zebu. Of these, a 250 kb selective sweep on chromosome 16 spans seven genes, including PLCH2, PEX10, PRKCZ, and SKI, which are involved in alternative adaptive metabolic strategies of insulin signalling, glucose homeostasis, and fat metabolism. Conclusions - Our results suggest that environmental adaptation may involve recent and ancient selection at generich regions, which might be under a common regulatory genetic control, in zebu cattle. |
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Palavras-Chave: |
Adaptação ao deserto; Zebu africano; Zebu sudanês. |
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Thesagro: |
Gado Zebu; Insulina; Metabolismo Animal. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1144851/1/Genomic-signatures-for-drylands-adaptation-at-gene-rich-regions-in-African-zebu-cattle.pdf
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Marc: |
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024 7 $ahttps://doi.org/10.1016/j.ygeno.2022.110423$2DOI
100 1 $aTIJJANI, A.
245 $aGenomic signatures for drylands adaptation at gene-rich regions in African zebu cattle.$h[electronic resource]
260 $c2022
520 $aBackground - Indigenous Sudanese cattle are mainly indicine/zebu (humped) type. They thrive in the harshest dryland environments characterised by high temperatures, long seasonal dry periods, nutritional shortages, and vector disease challenges. Here, we sequenced 60 indigenous Sudanese cattle from six indigenous breeds and analysed the data using three genomic scan approaches to unravel cattle adaptation to the African dryland region. Results - We identified a set of gene-rich selective sweep regions, detected mostly on chromosomes 5, 7 and 19, shared across African and Gir zebu. These include genes involved in immune response, body size and conformation, and heat stress response. We also identified selective sweep regions unique to Sudanese zebu. Of these, a 250 kb selective sweep on chromosome 16 spans seven genes, including PLCH2, PEX10, PRKCZ, and SKI, which are involved in alternative adaptive metabolic strategies of insulin signalling, glucose homeostasis, and fat metabolism. Conclusions - Our results suggest that environmental adaptation may involve recent and ancient selection at generich regions, which might be under a common regulatory genetic control, in zebu cattle.
650 $aGado Zebu
650 $aInsulina
650 $aMetabolismo Animal
653 $aAdaptação ao deserto
653 $aZebu africano
653 $aZebu sudanês
700 1 $aSALIM, B.
700 1 $aSILVA, M. V. G. B.
700 1 $aELTAHIR, H. A.
700 1 $aMUSA, T. H.
700 1 $aMARSHALL, K.
700 1 $aHANOTTE, O.
700 1 $aMUSA, H. H.
773 $tGenomics$gv. 114, 110423, 2022.
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Embrapa Gado de Leite (CNPGL) |
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